Managing Pediatric
Patients

GENTLE AND PREDICTABLE FLUID REMOVAL

MANAGING FLUID OVERLOAD IN PEDIATRIC PATIENTS (≥ 20KG)

In critically ill pediatric patients, managing fluid balance is crucial in reducing the risk of morbidity and mortality.

Pediatric

THE CHALLENGE WITH FLUID OVERLOAD

  • Fluid overload is associated with significant increases in mortality in pediatric patients1,2
  • In a pediatric study, a 3% increase in mortality was observed for every 1% increase in fluid overload (FO),1,2 children with more than 20% FO had an odds ratio for mortality of 8.5 compared with children with less than 20% FO1,2
  • Diuretics and adult CRRT devices can be poorly tolerated by pediatric patients3-6
  • Ultrafiltration therapy with a device containing small extracorporeal volume (ECV) may be better tolerated than CRRT machines with larger ECV in relation to patient blood volume7

PREDICTABLE OUTCOMES WITH AQUADEX

SAFE

  • Safe and effective for pediatric patients (≥ 20kg) who are fluid overloaded and fail diuretics
  • Only requires approximately 35 mL of ECV in the blood circuit
  • Low maximum blood flow rate (40mL/min) helps prevent hemodynamic stress associated with excessive fluid removal
  • Low maximum ultrafiltration rate (500 mL/hr) reduces the risk associated with removing fluid at high rates in smaller patients

GENTLE

  • An alternative to diuretics and other CRRT therapies that can be less effective, less efficient, or not well-tolerated3-6

SMART

  • Filter Alert prompts action to extend filter life and reduce therapy time
  • Hct informs therapy titration and termination decisions
  • Sv02 helps determine the amount of oxygen delivered to the body and guide therapy decisions
  • Track fluid removed more easily compared with today’s manual process

CLICK AN INDICATION TO EXPLORE THE IMPACT OF AQUADEX

Heart Failure

Heart failure

Critical Care

Critical care

[1] Sutherland SM, et al. American Journal of Kidney Diseases, vol. 55, no. 2, pp. 316-325, February 2010. [2] Gillespie RS, et al. Pediatric Nephrology, vol. 19, no. 12, pp. 1394-1399, December 2004. [3] Wang S, et al. Perfusion., vol. 27, no. 5, pp. 438-46, Sep 2012. [4] Askenazi D, et al. Pediatr Nephrol., vol. 31, no. 5, pp. 853-860, May 2016. [5] Chakravarti S, et al. Pediatr Rep., vol. 8, no. 2, p. 6596, 23 Jun 2016. [6] Raina R, et al.  PLoS ONE, vol. 12, no. 5, p. e0178233, 30 May 2017. [7] Menon S, et al. CJSN, Vol 14 October 2019.

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