Heart Failure
Evidence

EVIDENCE FOR HEART FAILURE PATIENTS

The Aquadex® System has been studied in more patients than any other ultrafiltration system.

CLINICAL STUDIES

Highest level of evidence: Level 1 (randomized clinical trial)1

THE CARRESS-HF STUDY

A reflection on the original findings and what has been learned since 2012.

KEY TAKEAWAYS
Ultrafiltration vs. pharmacological therapy was associated with more fluid removal but also rise in serum creatinine and neurohormonal activation. Additionally, loop diuretic use vs. UF was associated with an increase in serum bicarbonate despite less decongestion, data which question the commonly held conception of a ‘contraction alkalosis’.

Ten years of real-world data with ultrafiltration (UF) for the management of ADHF patients

Retrospective, single-center analysis of 335 consecutive acutely decompensated heart failure patients treated with adjustable-rate ultrafiltration using the Aquadex FlexFlow® System from 7/28/2009 to 6/30/2019.

Review poster

KEY TAKEAWAYS

  • All patients had stable renal function at follow-up
  • Compared with previous UF trials (UNLOAD, CARRESS & AVOID), real-world experience demonstrates that UF compares favorably for HF re-hospitalizations, renal function response, and weight/volume loss
  • Real-world experience allowed for the adjustment of UF rate during therapy, which contributed to favorable outcomes
  • UF is a safe and effective strategy for decongestion
  • Hospitalizations per patient per year decreased, on average, by 81%  from twice a year to once every two and a half years
  • Rehospitalizations for patients after receiving ultrafiltration with Aquadex was 48% less than the National Average at 30 days

AQUADEX IN AN OUTPATIENT SETTING

META-ANALYSES OF ULTRAFILTRATION

PEER REVIEWS

AQUADEX IN HEALTHCARE ECONOMICS

AQUADEX CASE STUDIES

PROFESSIONAL SOCIETY GUIDELINES

Professional societies provide valuable support to the medical community. Their focus on ethics and advancing clinical standards are essential to improving the quality of care. Ultrafiltration is supported in the following clinical guidelines:

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